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Curr Microbiol. 2014 Feb;68(2):174-9. doi: 10.1007/s00284-013-0453-z. Epub 2013 Sep 22.

PBP deletion mutants of Escherichia coli exhibit irregular distribution of MreB at the deformed zones.

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Department of Biotechnology, Indian Institute of Technology Kharagpur (IIT Kgp), Kharagpur, 721302, India,


MreB is a cytoskeletal protein, which is responsible for maintaining proper cellular morphology and is essential for cell survival. Likewise, penicillin-binding protein 5 (PBP5) helps in maintaining cell shape, though non-essential for survival. The contradicting feature of these two proteins paves the way for this study, wherein we attempt to draw a relation on the nature of distribution of MreB in PBP deletion mutants. The study revealed that the uniform MreB helices/patches were destabilized/disturbed at the zone of deformities of the PBP mutants, whereas the helical patterns were retained at the regions maintaining a rod shape. We interpret that MreB remains functional irrespective of its distribution being misguided by the aberrant shapes of PBP mutants.

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