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Nat Immunol. 2013 Nov;14(11):1190-8. doi: 10.1038/ni.2712. Epub 2013 Sep 22.

Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation.

Author information

1
1] Systems Biology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA. [2].

Abstract

Although intergenic long noncoding RNAs (lincRNAs) have been linked to gene regulation in various tissues, little is known about lincRNA transcriptomes in the T cell lineages. Here we identified 1,524 lincRNA clusters in 42 T cell samples, from early T cell progenitors to terminally differentiated helper T cell subsets. Our analysis revealed highly dynamic and cell-specific expression patterns for lincRNAs during T cell differentiation. These lincRNAs were located in genomic regions enriched for genes that encode proteins with immunoregulatory functions. Many were bound and regulated by the key transcription factors T-bet, GATA-3, STAT4 and STAT6. We found that the lincRNA LincR-Ccr2-5'AS, together with GATA-3, was an essential component of a regulatory circuit in gene expression specific to the TH2 subset of helper T cells and was important for the migration of TH2 cells.

PMID:
24056746
PMCID:
PMC3805781
DOI:
10.1038/ni.2712
[Indexed for MEDLINE]
Free PMC Article

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