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J Pharm Biomed Anal. 2014 Jan;88:136-43. doi: 10.1016/j.jpba.2013.08.031. Epub 2013 Aug 31.

Screening for multiple weight loss and related drugs in dietary supplement materials by flow injection tandem mass spectrometry and their confirmation by liquid chromatography tandem mass spectrometry.

Author information

1
Food and Drug Administration, Method Development and Total Diet Research Center, 11630 W. 80th Street, Lenexa, KS 66214, United States. Electronic address: fenhong.song@fda.hhs.gov.

Abstract

A new method has been developed using flow injection tandem mass spectrometry to semi-quantitatively screen for weight loss drugs, including sibutramine, N-desmethylsibutramine, N-didesmethylsibutramine, and phenolphthalein in dietary supplements. Positive identification of these drugs in samples was further confirmed and quantified by liquid chromatography tandem mass spectrometry. The degradation products of sibutramine were observed and identified by LC-MS/MS which include N-desmethylsibutramine, N-didesmethylsibutramine, N-formyldesmethylsibutramine, and N-formyldidesmethylsibutramine.

KEYWORDS:

Dietary supplement; Flow injection; LC–MS/MS; Sibutramine; Weight loss drugs

PMID:
24055849
DOI:
10.1016/j.jpba.2013.08.031
[Indexed for MEDLINE]
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