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Drug Discov Today. 2014 Feb;19(2):164-70. doi: 10.1016/j.drudis.2013.09.008. Epub 2013 Sep 17.

Lipidomics in drug discovery.

Author information

1
Zora Biosciences Oy, Biologinkuja 1, 02150 Espoo, Finland.
2
Zora Biosciences Oy, Biologinkuja 1, 02150 Espoo, Finland. Electronic address: reijo.laaksonen@zora.fi.

Abstract

Lipidomics is a rapidly growing technology that can be used in biomedical research to study disease mechanisms, identify novel disease biomarkers and drug efficacy biomarkers, and reveal off-target effects. Lipidomics can also be used to elucidate the mechanism of action of different drug compounds or as readouts in Mendelian randomization approaches. Furthermore, lipidomics can be utilized to identify deviations in metabolic and/or signaling pathways in different stages of disease. Therefore, as we discuss here, this emerging technology also has a substantial potential in various drug discovery programs.

PMID:
24055840
DOI:
10.1016/j.drudis.2013.09.008
[Indexed for MEDLINE]

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