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Virus Res. 2013 Dec 26;178(2):543-6. doi: 10.1016/j.virusres.2013.09.017. Epub 2013 Sep 18.

Identification of two severe fever with thrombocytopenia syndrome virus strains originating from reassortment.

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1
College of Life Science, Shandong Normal University, Jinan 250014, China.

Abstract

Recently, a novel bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV), was isolated in central China. The virus can cause multi-clinical symptoms: severe fever, thrombocytopenia, leukocytopenia, with a mortality rate of ~10%. Several studies show that SFTSV could undergo rapid evolution via gene mutation and homologous recombination. However, as an important evolutionary force for segmented-genome viruses, reassortment has not been reported in SFTSV. In this study, we identified two SFTSV strains of which the S segment has different origin from M and L, suggesting that reassortment might be potential force driving rapid change of SFTSV. This result might shed new light on the evolutionary behavior of the novel virus.

KEYWORDS:

Reassortment; Severe fever with thrombocytopenia syndrome virus

PMID:
24055465
DOI:
10.1016/j.virusres.2013.09.017
[Indexed for MEDLINE]
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