Format

Send to

Choose Destination
Biochem Biophys Res Commun. 2013 Oct 11;440(1):168-72. doi: 10.1016/j.bbrc.2013.09.057. Epub 2013 Sep 18.

Expression of aquaporin8 in human astrocytomas: correlation with pathologic grade.

Author information

1
Institute of Neurobiological Sciences, Faculty of Basic Medical Science of Chongqing Medical University, Medical College Road 1, YuanJiaGang, YuZhong District, Chongqing 400016, People's Republic of China.

Abstract

Aquaporin8 (AQP8), a member of the aquaporin (AQP) protein family, is weakly distributed in mammalian brains. Previous studies on AQP8 have focused mainly on the digestive and the reproductive systems. AQP8 has a pivotal role in keeping the fluid and electrolyte balance. In this study, we investigated the expression changes of AQP8 in 75 cases of human brain astrocytic tumors using immunohistochemistry, Western blotting, and reverse transcription polymerase chain reaction. The results demonstrated that AQP8 was mainly distributed in the cytoplasm of astrocytoma cells. The expression levels and immunoreactive score of AQP8 protein and mRNA increased in low-grade astrocytomas, and further increased in high-grade astrocytomas, especially in glioblastoma. Therefore, AQP8 may contribute to the proliferation of astrocytomas, and may be a biomarker and candidate therapy target for patients with astrocytomas.

KEYWORDS:

Aquaporin-8; Astrocytic tumors; Pathologic grade

PMID:
24055034
DOI:
10.1016/j.bbrc.2013.09.057
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center