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Int J Radiat Oncol Biol Phys. 2013 Nov 15;87(4):646-50. doi: 10.1016/j.ijrobp.2013.07.038. Epub 2013 Sep 18.

Probiotics for rectal volume variation during radiation therapy for prostate cancer.

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1
Department of Radiation Oncology, Pusan National University School of Medicine, Busan, Republic of Korea.

Abstract

PURPOSE:

To investigate the effect of the probiotic Lactobacillus acidophilus on the percentage volume change of the rectum (PVCR), a crucial factor of prostate movement.

METHODS AND MATERIALS:

Prostate cancer patients managed with tomotherapy as a radical treatment were enrolled in the study to take a probiotic capsule containing 1.0×10(8) colony-forming units of L acidophilus or a placebo capsule twice daily. Radiation therapy was performed at a dose of 78 Gy in 39 fractions. The PVCR, defined as the difference in rectal volume between the planning computed tomographic (CT) and daily megavoltage CT images, was analyzed.

RESULTS:

Forty patients were randomized into 2 groups. The L acidophilus group showed significantly lower median rectal volume and median PVCR values than the placebo group. L acidophilus showed a significant reduction effect on the PVCR (P<.001). However, the radiation therapy fraction number did not significantly influence the PVCR.

CONCLUSIONS:

L acidophilus was useful in reducing the PVCR, which is the most important determining factor of prostate position, during radiation therapy for prostate cancer.

PMID:
24054874
DOI:
10.1016/j.ijrobp.2013.07.038
[Indexed for MEDLINE]
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