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Presse Med. 2013 Oct;42(10):1398-404. doi: 10.1016/j.lpm.2013.07.012. Epub 2013 Sep 18.

[Vitamin D and neurology].

[Article in French]

Author information

1
Hôpital Carémeau, service de neurologie, place du Pr-Debré, 30029 Nîmes cedex 9, France.

Abstract

Vitamin D deficiency is associated with a higher risk of multiple sclerosis and also with a higher relapse rate as well as a higher number of MRI lesions. Elders with vitamin D deficiency have worse cognitive performance. Vitamin D deficiency is a risk factor for developing Alzheimer's disease. Ischemic stroke are more frequent and more severe in patients with low vitamin D levels. Carotid atherosclerosis is more frequent and more severe in patients with vitamin D deficiency. Vitamin D deficiency is associated with a higher risk and worse prognosis of Parkinson's disease. In the different neurological disorders discussed herein, gene polymorphisms that could alter vitamin D metabolism are also associated with a higher incidence or a worse disease prognosis. Despite the links between vitamin D deficiency and the risks of developing neurological disorders, there is, to date, no proof that supplementation could alter the course of these diseases.

PMID:
24054766
DOI:
10.1016/j.lpm.2013.07.012
[Indexed for MEDLINE]
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