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Acta Paediatr. 2014 Jan;103(1):27-37. doi: 10.1111/apa.12421. Epub 2013 Oct 30.

EXPRESS study shows significant regional differences in 1-year outcome of extremely preterm infants in Sweden.

Author information

1
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden; Department of Pediatrics, Institute of Clinical Sciences, Umeå University, Umeå, Sweden.

Abstract

AIM:

The aim of this study was to investigate differences in mortality up to 1 year of age in extremely preterm infants (before 27 weeks) born in seven Swedish healthcare regions.

METHODS:

National prospective observational study of consecutively born, extremely preterm infants in Sweden 2004-2007. Mortality was compared between regions. Crude and adjusted odds ratios and 95% CI were calculated.

RESULTS:

Among 844 foetuses alive at mother's admission for delivery, regional differences were identified in perinatal mortality for the total group (22-26 weeks) and in the stillbirth and perinatal and 365-day mortality rates for the subgroup born at 22-24 weeks. Among 707 infants born alive, regional differences were found both in mortality before 12 h and in the 365-day mortality rate for the subgroup (22-24 weeks) and for the total group (22-26 weeks). The mortality rates were consistently lower in two healthcare regions. There were no differences in the 365-day mortality rate for infants alive at 12 h or for infants born at 25 weeks. Neonatal morbidity rates among survivors were not higher in regions with better survival rates. Perinatal practices varied between regions.

CONCLUSION:

Mortality rates in extremely preterm infants varied considerably between Swedish healthcare regions in the first year after birth, particularly between the most immature infants.

KEYWORDS:

Cohort study; Extremely preterm infant; Morbidity; Mortality; Outcome

PMID:
24053771
PMCID:
PMC4034585
DOI:
10.1111/apa.12421
[Indexed for MEDLINE]
Free PMC Article

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