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BJU Int. 2014 Mar;113 Suppl 2:29-34. doi: 10.1111/bju.12458.

Comparison of contemporary methods for estimating prostate tumour volume in pathological specimens.

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1
Western Health, Melbourne, VIC, Australia.

Abstract

OBJECTIVE:

To evaluate the accuracy of various prostate tumour volume (TV) estimation methods. To determine the most appropriate estimation method for current clinical practice.

PATIENTS AND METHODS:

Radical prostatectomy (RP) specimens from multiple institutions were analysed by a single uro-pathologist between September 2009 and May 2011. Tumour properties including thickness, width and length were collected and TV was established using computer-assisted image analysis (CAIA). TV estimation methods including; square, cuboidal and ellipsoidal estimations were calculated using previously reported formulae. The estimation methods were compared against the 'gold-standard' and the accuracy of identifying clinically significant tumours of TV ≥0.5 cc was determined.

RESULTS:

In all, 299 consecutive specimens were analysed by a single uropathologist. The median index TV on CAIA was 1.42 cc. Of the four estimation methods, the ellipsoid methods produced the closest correlation with the gold-standard (r(2) 0.91, P = 0.71). This correlation lost accuracy when larger tumours (TV >4 cc) were excluded from the analysis (r(2) = 0.73, P = 0.003). Sensitivity and specificity for identifying clinically significant tumours was 94% and 92% respectively, when using the ellipsoid estimation.

CONCLUSIONS:

In current uro-pathology, the ellipsoidal estimation method appears to be the most suitable for estimating TV in prostate cancers. This method is cheap, reproducible and sensitive and can be safely used as a surrogate for CAIA volumes when such technology is not available.

KEYWORDS:

computer-assisted/methods; image processing; male; prostatectomy; prostatic neoplasms/pathology; prostatic neoplasms/surgery

PMID:
24053510
DOI:
10.1111/bju.12458
[Indexed for MEDLINE]
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