Format

Send to

Choose Destination
Nature. 1990 Jan 18;343(6255):233-8.

Regulation of microtubule dynamics by cdc2 protein kinase in cell-free extracts of Xenopus eggs.

Author information

1
European Molecular Biology Laboratory, Cell Biology Program, Heidelberg, FRG.

Abstract

Microtubules are involved in the transport of vesicles in interphase and of the chromosomes during mitosis. Their arrangement and orientation in the cell are therefore of prime importance and specific patterns are believed to be generated by modulations of the intrinsic dynamic instability of microtubules. Here it is shown that the interphase-metaphase transition of microtubule arrays is under the control of the cdc2 kinase that precisely regulates the dynamics and steady-state length of microtubules.

PMID:
2405278
DOI:
10.1038/343233a0
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center