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Med Princ Pract. 2014;23(1):29-33. doi: 10.1159/000354758. Epub 2013 Sep 13.

Primary cytomegalovirus infection in pregnant Egyptian women confirmed by cytomegalovirus IgG avidity testing.

Author information

1
Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Abstract

OBJECTIVE:

To determine the frequency of primary cytomegalovirus (CMV) infection in pregnant Egyptian women using CMV IgG avidity testing.

SUBJECTS AND METHODS:

A cross-sectional study was conducted at Suez Canal University Hospital, Ismailia, Egypt. A total of 546 pregnant women, presenting for routine antenatal screening, were tested for CMV IgG and IgM using a commercially available enzyme-linked immunosorbent assay (ELISA). Sera from CMV IgM-positive women were tested by CMV IgG avidity assay.

RESULTS:

All the 546 pregnant women were seropositive for anti-CMV IgG. Of the 546 women, 40 (7.3%) were positive or equivocal for IgM antibodies. All sera from the 40 women (IgG+/IgM+) showed a high or intermediate CMV IgG avidity index. Of the 40 women, 23 (57.5%) were in the second or third trimesters of pregnancy and had their first-trimester blood retrieved, and the tested CMV IgG avidity assay showed a high avidity index.

CONCLUSION:

Women who were IgM positive had no primary CMV infection in the index pregnancy as evidenced by the high CMV IgG avidity testing.

PMID:
24052007
PMCID:
PMC5586833
DOI:
10.1159/000354758
[Indexed for MEDLINE]
Free PMC Article

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