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Complement Ther Med. 2013 Oct;21(5):447-52. doi: 10.1016/j.ctim.2013.07.003. Epub 2013 Aug 7.

Capparis spinosa L. (Caper) fruit extract in treatment of type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial.

Author information

1
Pharmacology and Applied Medicine Department of Medicinal Plants research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran.

Abstract

OBJECTIVES:

Capparis spinosa L. (Caper) fruit is traditionally used as an anti-hyperglycemic food by Iranian diabetic patients. But yet, no controlled human study has determined its efficacy in treatment of hyperglycemia in type 2 diabetic patients.

DESIGN:

The present study was undertaken to explore the possible anti-hyperglycemic effects of the caper fruit extract in type 2 diabetic patients. A randomized clinical trial was conducted in 54 type 2 diabetic patients. Two groups 28 and 26 patients on standard anti-diabetic therapy, received 400mg caper fruit extract and placebo capsules three times a day respectively for two months.

MAIN OUTCOME MEASURES:

The patients fasting blood glucose, glycosylated hemoglobin, lipids levels, liver and renal function tests were determined at baseline and endpoint.

RESULTS:

Results showed significant decrease in fasting blood glucose levels (p=0.037) and glycosylated hemoglobin (p=0.043) in caper treated patients compared to control group at the end of the study. Triglyceride level also decreased significantly (p=0.29) in caper treated group at the end of the study compared to baseline. No liver, kidney and other side effects were observed in these two groups.

CONCLUSIONS:

Caper fruit extract may be a safe anti-hyperglycemic and anti-hypertriglyceridemic agent for type 2 diabetic patients.

KEYWORDS:

Capparis spinosa; Clinical trial; Diabetes; Medicinal plants

PMID:
24050578
DOI:
10.1016/j.ctim.2013.07.003
[Indexed for MEDLINE]

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