Zebrafish cancer and metastasis models for in vivo drug discovery

Jennifer Tat; Mingyao Liu; Xiao-Yan Wen

doi:10.1016/j.ddtec.2012.04.006

Zebrafish cancer and metastasis models for in vivo drug discovery

Drug Discov Today Technol. 2013 Spring;10(1):e83-9. doi: 10.1016/j.ddtec.2012.04.006.

Authors

Jennifer Tat, Mingyao Liu, Xiao-Yan Wen

PMID: 24050234
DOI: 10.1016/j.ddtec.2012.04.006

Abstract

There is a great need for more efficient methods to discover new cancer therapeutics, as traditional drug development processes are slow and expensive. The use of zebrafish as a whole-organism screen is a time and cost-effective means of improving the efficiency and efficacy of drug development. This review features zebrafish genetic and cell transplantation models of cancer and metastasis, and current imaging and automation technologies that, together, will significantly advance the field of anti-cancer drug discovery.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Disease Models, Animal*
Drug Discovery
Neoplasm Metastasis*
Neoplasms / pathology*
Zebrafish* / genetics