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Drug Discov Today Technol. 2013 Spring;10(1):e65-71. doi: 10.1016/j.ddtec.2012.09.004.

A Drosophila approach to thyroid cancer therapeutics.

Abstract

Thyroid neoplasias represent among the fastest growing cancers. While surgery has become the treatment of choice for most thyroid tumors, many require chemotherapy. In this review, we examine the contributions of work in the fruit fly Drosophila toward multiple endocrine neoplasia type 2 (MEN2), a Ret-based disease to which recent Drosophila models have proven useful both for understanding disease mechanism as well as helping identify new generation therapeutics.

PMID:
24050232
PMCID:
PMC3779345
DOI:
10.1016/j.ddtec.2012.09.004
[Indexed for MEDLINE]
Free PMC Article

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