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Public Health Nutr. 2014 Sep;17(9):2087-93. doi: 10.1017/S1368980013002553. Epub 2013 Sep 19.

Oestrogen levels in serum and urine of premenopausal women eating low and high amounts of meat.

Author information

1
1University of Hawaii Cancer Center,701 Ilalo Street,Honolulu,HI 96813,USA.
2
2University of Southern California,Los Angeles,CA,USA.

Abstract

OBJECTIVE:

Based on the hypothesis that high-meat diets may increase breast cancer risk through hormonal pathways, the present analysis compared oestrogens in serum and urine by meat-eating status.

DESIGN:

Intervention with repeated measures.

SETTING:

Two randomized soya trials (BEAN1 and BEAN2) among premenopausal healthy women.

SUBJECTS:

BEAN1 participants completed seven unannounced 24 h dietary recalls and donated five blood and urine samples over 2 years. BEAN2 women provided seven recalls and three samples over 13 months. Serum samples were analysed for oestrone (E₁) and oestradiol (E₂) using RIA. Nine oestrogen metabolites were measured in urine by LC-MS. Semi-vegetarians included women who reported consuming <30 g of red meat, poultry and fish daily, and pescatarians those who reported consuming <20 g of meat/poultry but >10 g of fish daily. All other women were classified as non-vegetarians. We applied mixed models to compute least-square means by vegetarian status adjusted for potential confounders.

RESULTS:

The mean age of the 272 participants was 41·9 (SD 4·5) years. Serum E₁ (85 v. 100 pg/ml, P = 0·04) and E₂ (140 v. 154 pg/ml, P = 0·04) levels were lower in the thirty-seven semi-vegetarians than in the 235 non-vegetarians. The sum of the nine urinary oestrogen metabolites (183 v. 200 pmol/mg creatinine, P = 0·27) and the proportions of individual oestrogens and pathways did not differ by meat-eating status. Restricting the models to the samples collected during the luteal phase strengthened the associations.

CONCLUSIONS:

Given the limitations of the study, the lower levels of serum oestrogens in semi-vegetarians than non-vegetarians need confirmation in larger populations.

PMID:
24050121
PMCID:
PMC4231431
DOI:
10.1017/S1368980013002553
[Indexed for MEDLINE]
Free PMC Article
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