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Caspian J Intern Med. 2011 Summer;2(3):279-82.

Comparison of the effect of fish oil and ibuprofen on treatment of severe pain in primary dysmenorrhea.

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Department of Midwifery, Islamic Azad University, Sari Branch, Sari, Iran.


Background : Primary dysmenorrhea is common among young girls and child-bearing women. The purpose of this study was to compare the efficacy of fish oil and Ibuprofen on the treatment of primary dysmenorrhea.


This clinical trial study was done on students of Babol University of Medical Sciences in 2010. One hundred- twenty students who had moderate and severe dysmenorrhea were randomly divided in two groups. The first group (0 girls) received 1000 mg/day fish oil capsule in all her cycle days and the second group received mg ibuprofen when their pain started (duration of this study was months). Student t-test, Mann Whitney and Freidman tests were used when appropriate. This clinical trial was registered in the Iranian Registry of clinical Trials (www.IRCT.Ir) (IR21101133004N4).


There was a significant difference between the intensity of pain before and after treatment by ibuprofen (p=1) and fish oil (p=1). Furthermore, the reduction of pain in fish oil recipient was higher than the IBV prefer group (p=0001).


The results show that the efficacy of fish oil is better than ibuprofen on treatment of severe pain in primary dysmenorrhea.


Dysmenorrhea; Fish oil; Ibuprofen; Primary; Treatment


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