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Clin Interv Aging. 2013;8:1119-31. doi: 10.2147/CIA.S49737. Epub 2013 Sep 12.

Promoting physical activity for elders with compromised function: the lifestyle interventions and independence for elders (LIFE) study physical activity intervention.

Collaborators (205)

Pahor M, Guralnik JM, Anton SD, Buford TW, Leeuwenburgh C, Nayfield SG, Manini TM, Caudle C, Crump L, Holmes L, Lee J, Lester R, Lu CJ, Miller ME, Espeland MA, Ambrosius WT, Applegate W, Babcock D, Beavers DP, Byington RP, Cook D, Furberg CD, Goode C, Griffin J, Harvin LN, Henkin L, Hepler J, Hsu FC, Joyce K, Lovato L, Roberson W, Robertson J, Rushing J, Rushing S, Stowe CL, Walkup MP, Hire D, Rejeski WJ, Katula JA, Brubaker PH, Mihalko SL, Jennings JM, Lane K, Luopa J, Moore S, Teuschler HV, Hadley EC, Romashkan S, Bonds DE, Patel KV, McDermott MM, Spring B, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Church TS, Blair SN, Myers VH, Britt NE, Harris MN, McGucken AP, Rodarte R, Millet HK, Tudor-Locke C, Butitta BP, Donatto SG, Cocreham SH, King AC, Castro CM, Haskell WL, Stafford RS, Yank V, Pruitt LA, Berra K, Bell C, Thiessen RM, Youngman KP, Virgen SB, Maldonado E, Tarin KN, Klaftenegger H, Prosak CA, Campero I, Garcia DM, Soto J, Chio L, Hoskins D, Fielding RA, Nelson ME, Folta SC, Phillips EM, Liu CK, Cifarelli EC, Reid KF, Lacasse PC, Kirn DR, Pasha EP, Ruais KR, Kim WS, Krol JM, Beard VE, Tsiroyannis EX, Hau C, Manini TM, Pahor M, Anton SD, Buford TW, Marsiske M, Nayfield SG, Sandesara BD, Black ML, Burk WL, Hoover BM, Knaggs JD, Marena WC, Korytov I, Curtis SD, Lorow MS, Goswami CS, Lewis MA, Kamen M, Bitz JN, Stanton BK, Hicks TT, Gay CW, Xie C, Morris HL, Singletary FF, Causer J, Yonce S, Radcliff KA, Smith MP, Scott JS, Rodriguez MM, Fitch MS, Dunn MC, Schllesinger JQ, Newman AB, Studenski SA, Goodpaster BH, Lopez O, Glynn NW, Nadkarni NK, Ives DG, Newman MA, Grove G, Williams K, Bonk JT, Rush J, Kost P, Vincent P, Gerger A, Romeo J, Monheim LC, Kritchevsky SB, Marsh AP, Brinkley TE, Demons JS, Sink KM, Kennedy K, Shertzer-Skinner R, Wrights A, Fries R, Barr D, Gill TM, Axtell RS, Kashaf SS, de Rekeneire N, McGloin JM, Wu KC, Iannone LP, Mautner R, Shepard DM, Fennelly B, Barnett TS, Halpin SN, Brennan MJ, Bugaj JA, Zenoni MA, Mignosa BM, Huie-White SM, Zocher J, Williamson J, Sink KM, Hendrie HC, Rapp SR, Verghese J, Woolard N, Espeland M, Jennings J, Pepine CJ, Ariet M, Handberg E, Deluca D, Hill J, Szady A, Chupp GL, Flynn GM, Gill TM, Hankinson JL, Fragoso CA, Groessl EJ, Kaplan RM.

Author information

Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, USA.


The Lifestyle Interventions and Independence for Elders (LIFE) Study is a Phase III randomized controlled clinical trial ( identifier: NCT01072500) that will provide definitive evidence regarding the effect of physical activity (PA) on major mobility disability in older adults (70-89 years old) who have compromised physical function. This paper describes the methods employed in the delivery of the LIFE Study PA intervention, providing insight into how we promoted adherence and monitored the fidelity of treatment. Data are presented on participants' motives and self-perceptions at the onset of the trial along with accelerometry data on patterns of PA during exercise training. Prior to the onset of training, 31.4% of participants noted slight conflict with being able to meet the demands of the program and 6.4% indicated that the degree of conflict would be moderate. Accelerometry data collected during PA training revealed that the average intensity - 1,555 counts/minute for men and 1,237 counts/minute for women - was well below the cutoff point used to classify exercise as being of moderate intensity or higher for adults. Also, a sizable subgroup required one or more rest stops. These data illustrate that it is not feasible to have a single exercise prescription for older adults with compromised function. Moreover, the concept of what constitutes "moderate" exercise or an appropriate volume of work is dictated by the physical capacities of each individual and the level of comfort/stability in actually executing a specific prescription.


accelerometry; aging; compromised physical function; older adults; physical disability

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