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Hum Reprod. 2013 Nov;28(11):2893-7. doi: 10.1093/humrep/det359. Epub 2013 Sep 17.

Neonatal uterine bleeding as antecedent of pelvic endometriosis.

Author information

1
Leuven Institute for Fertility and Embryology, Oud-Heverleestraat 83, 30001 Leuven, Belgium.

Abstract

We elaborate on a new theory to explain pelvic endometriosis, including endometriosis in premenarcheal girls, based on the finding that the neonatal endometrium can display secretory activity immediately after birth and, in some cases, changes analogous to those seen at menstruation in adults. The neonatal uterus is therefore capable of shedding its endometrium. Indeed, occult vaginal bleeding occurs in a majority of neonates, although overt bleeding is estimated to occur in only 5% of neonates. This may be due to functional plugging of the endocervical canal in the neonate, which in turn would promote retrograde flux of endometrial cells contained in menstrual debris. Ectopic endometrial implantation in a newborn with hydrometrocolpos has been documented. These data, coupled with the observation of a significantly increased risk of endometriosis in adolescents with cervical outflow obstruction and patent Fallopian tubes, indicate that endometriosis, especially in children and young adolescents, may originate from retrograde uterine bleeding soon after birth.

KEYWORDS:

cervical obstruction; fetal uterus; neonatal uterine bleeding; pelvic endometriosis; retrograde menstruation

PMID:
24048011
DOI:
10.1093/humrep/det359
[Indexed for MEDLINE]

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