Format

Send to

Choose Destination
Future Med Chem. 2013 Sep;5(14):1685-700. doi: 10.4155/fmc.13.130.

Therapeutic strategies impacting cancer cell glutamine metabolism.

Author information

1
Department of Molecular Medicine, Cornell University, Ithaca, NY 14850-6401, USA.

Abstract

The metabolic adaptations that support oncogenic growth can also render cancer cells dependent on certain nutrients. Along with the Warburg effect, increased utilization of glutamine is one of the metabolic hallmarks of the transformed state. Glutamine catabolism is positively regulated by multiple oncogenic signals, including those transmitted by the Rho family of GTPases and by c-Myc. The recent identification of mechanistically distinct inhibitors of glutaminase, which can selectively block cellular transformation, has revived interest in the possibility of targeting glutamine metabolism in cancer therapy. Here, we outline the regulation and roles of glutamine metabolism within cancer cells and discuss possible strategies for, and the consequences of, impacting these processes therapeutically.

PMID:
24047273
PMCID:
PMC4154374
DOI:
10.4155/fmc.13.130
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Central
Loading ...
Support Center