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Development. 2013 Oct;140(19):3939-49. doi: 10.1242/dev.080549.

The developmental origins of adipose tissue.

Author information

1
Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Abstract

Adipose tissue is formed at stereotypic times and locations in a diverse array of organisms. Once formed, the tissue is dynamic, responding to homeostatic and external cues and capable of a 15-fold expansion. The formation and maintenance of adipose tissue is essential to many biological processes and when perturbed leads to significant diseases. Despite this basic and clinical significance, understanding of the developmental biology of adipose tissue has languished. In this Review, we highlight recent efforts to unveil adipose developmental cues, adipose stem cell biology and the regulators of adipose tissue homeostasis and dynamism.

KEYWORDS:

Adipocyte; Adipose; Development; Niche; Stem cells; Vascular niche

PMID:
24046315
PMCID:
PMC3775412
DOI:
10.1242/dev.080549
[Indexed for MEDLINE]
Free PMC Article

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