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Nat Commun. 2013;4:2433. doi: 10.1038/ncomms3433.

The tiger genome and comparative analysis with lion and snow leopard genomes.

Author information

1
Personal Genomics Institute, Genome Research Foundation, Suwon 443-270, Republic of Korea.

Abstract

Tigers and their close relatives (Panthera) are some of the world's most endangered species. Here we report the de novo assembly of an Amur tiger whole-genome sequence as well as the genomic sequences of a white Bengal tiger, African lion, white African lion and snow leopard. Through comparative genetic analyses of these genomes, we find genetic signatures that may reflect molecular adaptations consistent with the big cats' hypercarnivorous diet and muscle strength. We report a snow leopard-specific genetic determinant in EGLN1 (Met39>Lys39), which is likely to be associated with adaptation to high altitude. We also detect a TYR260G>A mutation likely responsible for the white lion coat colour. Tiger and cat genomes show similar repeat composition and an appreciably conserved synteny. Genomic data from the five big cats provide an invaluable resource for resolving easily identifiable phenotypes evident in very close, but distinct, species.

PMID:
24045858
PMCID:
PMC3778509
DOI:
10.1038/ncomms3433
[Indexed for MEDLINE]
Free PMC Article

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