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Nat Chem Biol. 2013 Oct;9(10):605-6. doi: 10.1038/nchembio.1341.

Structural biology: Torqueing about pores.

Author information

1
Department of Biochemistry and Molecular Biology and the Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton, Melbourne, Victoria, Australia.

Abstract

Cryo-EM, crystallography, biochemical experiments and computational approaches have been used to study different intermediate states of the Aeromonas hydrophila toxin aerolysin en route to pore formation. These results reveal that an unexpected and marked rotation of the core aerolysin machinery is required to unleash the membrane-spanning regions.

PMID:
24045807
DOI:
10.1038/nchembio.1341
[Indexed for MEDLINE]

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