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Nat Rev Genet. 2013 Oct;14(10):719-32. doi: 10.1038/nrg3552.

Integrative approaches for finding modular structure in biological networks.

Author information

1
1] Department of Medicine, University of California San Diego, La Jolla, California 92093, USA. [2].

Abstract

A central goal of systems biology is to elucidate the structural and functional architecture of the cell. To this end, large and complex networks of molecular interactions are being rapidly generated for humans and model organisms. A recent focus of bioinformatics research has been to integrate these networks with each other and with diverse molecular profiles to identify sets of molecules and interactions that participate in a common biological function - that is, 'modules'. Here, we classify such integrative approaches into four broad categories, describe their bioinformatic principles and review their applications.

PMID:
24045689
PMCID:
PMC3940161
DOI:
10.1038/nrg3552
[Indexed for MEDLINE]
Free PMC Article

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