Identifying symptom co-occurrence in persons with multiple sclerosis

Clin Nurs Res. 2014 Oct;23(5):529-43. doi: 10.1177/1054773813497221. Epub 2013 Sep 17.

Abstract

Patients with multiple sclerosis (MS) experience a myriad of symptoms. There is some evidence that symptoms may co-occur, or happen in particular combinations. Yet most existing studies focus on single symptoms and practitioners make a priori care decisions based on individual symptoms alone. We examined symptom co-occurrences in patients with relapsing-remitting MS (RRMS), collecting qualitative and quantitative data (mixed methods; N = 140). Content analysis revealed fatigue, heat intolerance, numbness, balance problems, and leg weakness as the most common symptoms. Factor analysis revealed the following factors: urinary, problems with balance, vision, heat, depression, and sleep. These preliminary findings indicate co-occurrence of several disabling symptoms from the overall self-report MS-Related Symptom Scale and 3-month recall. This information will guide health care professionals in developing targeted interventions and improve outcomes.

Keywords: multiple sclerosis; nursing interventions; symptom co-occurrence.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adaptation, Physiological
  • Adult
  • Cross-Sectional Studies
  • Factor Analysis, Statistical
  • Fatigue
  • Female
  • Hot Temperature
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis / physiopathology*