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Int J Neuropsychopharmacol. 2014 Jul;17(7):983-96. doi: 10.1017/S1461145713000837. Epub 2013 Sep 18.

History, background, concepts and current use of comedication and polypharmacy in psychiatry.

Author information

1
Department of Psychiatry and Psychotherapy,Ludwig-Maximilians-University,Nussbaumstr.7, 80336 Munich,Germany.
2
Bezirkskrankenhaus Augsburg, Dr-Mack-Straße 1, 86156Augsburg.

Abstract

Based on a careful literature search a review is presented of the history, background, concepts and current use of comedication and polypharmacy in psychiatry. The pros and cons of comedication and polypharmacy are presented, as well as their apparent increase in recent times. Possible reasons for the increase of comedication/polypharmacy are described. Both the potential advantages as well as the potential risks are discussed. The one sided view that all comedication/polypharmacy is nothing but problematic is questioned. Comedication/polypharmacy seems to be, among others, the current answer to the well-known limited efficacy and effectiveness of current monotherapy treatment strategies.

PMID:
24044761
DOI:
10.1017/S1461145713000837
[Indexed for MEDLINE]

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