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Cancer Invest. 2013 Oct;31(8):555-62. doi: 10.3109/07357907.2013.834925. Epub 2013 Sep 18.

BMP4 is involved in the chemoresistance of myeloid leukemia cells through regulating autophagy-apoptosis balance.

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1
1Department of Hematology, Xiangya Hospital.

Abstract

This study showed that silencing BMP4 expression significantly activated caspase-2, 3, and 9, while decreasing Matrigel colony formation in Cytarabine (Ara-C)-treated leukemia HL-60 cells. In contrast, Ara-C significantly upregulated Atg5 and Beclin-1 expression, the ratio of LC3-II/LC3-I, and CDK1 and cyclin B1 expression in leukemia cells expressing BMP4. BafA significantly sensitized the apoptotic effect of Ara-C in leukemia cells. Injection of Ara-C significantly inhibited tumor growth in mice inoculated with leukemia cells with BMP4 silenced. In conclusion, BMP4 plays a crucial role in the chemoresistance of leukemia cells through the activation of autophagy and subsequent inhibition of apoptosis.

PMID:
24044460
DOI:
10.3109/07357907.2013.834925
[Indexed for MEDLINE]
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