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Cell Res. 2013 Nov;23(11):1251-3. doi: 10.1038/cr.2013.130. Epub 2013 Sep 17.

Plk1: unexpected roles in DNA replication.

Author information

1
Department of Gynecology and Obstetrics, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.

Abstract

FOR20, a conserved centrosomal protein, is essential for Plk1 to localize to the centrosome during the S phase and regulate DNA replication. The absence of either Plk1 or FOR20 can stall the cell cycle by a previously unknown intra-S phase centrosomal checkpoint.

PMID:
24042259
PMCID:
PMC3817549
DOI:
10.1038/cr.2013.130
[Indexed for MEDLINE]
Free PMC Article
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