Format

Send to

Choose Destination
Nature. 1990 Jan 11;343(6254):133-9.

Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment.

Author information

1
Department of Pharmacy, School of Pharmacy, University of California, San Francisco 94143.

Abstract

The pathways of intracellular traffic involved in antigen processing and presentation have been defined by immunoelectron microscopy. The export pathway for class II histocompatibility molecules and the antigen import pathway meet in a peripheral endocytic compartment having all the molecular machinery believed to be required for antigen processing and presentation, including internalized surface immunoglobulins, proteolytic enzymes and invariant chains. This compartment defines a site where peptides from endocytosed antigen can bind class II molecules en route to the cell surface for presentation to T cells.

PMID:
2404209
DOI:
10.1038/343133a0
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center