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Ageing Res Rev. 2013 Sep;12(4):907-17. doi: 10.1016/j.arr.2013.09.001. Epub 2013 Sep 14.

Actions of 17β-estradiol and testosterone in the mitochondria and their implications in aging.

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Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, San Juan 670, 8000 Bahía Blanca, Argentina. Electronic address:


A decline in the mitochondrial functions and aging are two closely related processes. The presence of estrogen and androgen receptors and hormone-responsive elements in the mitochondria represents the starting point for the investigation of the effects of 17β-estradiol and testosterone on the mitochondrial functions and their relationships with aging. Both steroids trigger a complex molecular mechanism that involves crosstalk between the mitochondria, nucleus, and plasma membrane, and the cytoskeleton plays a key role in these interactions. The result of this signaling is mitochondrial protection. Therefore, the molecular components of the pathways activated by the sexual steroids could represent targets for anti-aging therapies. In this review, we discuss previous studies that describe the estrogen- and testosterone-dependent actions on the mitochondrial processes implicated in aging.


17β-estradiol; Aging; Androgen receptor; Estrogen receptor; Mitochondria; Testosterone

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