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J Am Chem Soc. 2013 Sep 25;135(38):14012-5. doi: 10.1021/ja405919z. Epub 2013 Sep 16.

Palladium(III)-catalyzed fluorination of arylboronic acid derivatives.

Author information

1
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.
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Contributed equally

Abstract

A practical, palladium-catalyzed synthesis of aryl fluorides from arylboronic acid derivatives is presented. The reaction is operationally simple and amenable to multigram-scale synthesis. Evaluation of the reaction mechanism suggests a single-electron-transfer pathway, involving a Pd(III) intermediate that has been isolated and characterized.

PMID:
24040932
PMCID:
PMC3820116
DOI:
10.1021/ja405919z
[Indexed for MEDLINE]
Free PMC Article

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