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J Exp Med. 1990 Jan 1;171(1):307-14.

Migration of dendritic leukocytes from cardiac allografts into host spleens. A novel pathway for initiation of rejection.

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1
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, United Kingdom.

Abstract

It has been a long-standing dogma that host sensitization against fully-vascularized organ allografts occurs peripherally within the graft itself. In this report we show that donor-derived MHC class II-positive (Ia+) DL migrate rapidly out of mouse cardiac allografts into the recipients' spleens where they home to the peripheral white pulp and associate predominantly with CD4+ T lymphocytes. This provides a novel route for central sensitization against fully vascularized allografts, and most likely represents a pathway by which immune responses are generated against antigens on blood-borne DL emigrating from peripheral tissues.

PMID:
2404081
PMCID:
PMC2187651
[Indexed for MEDLINE]
Free PMC Article
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