Format

Send to

Choose Destination
PLoS One. 2013 Sep 6;8(9):e74641. doi: 10.1371/journal.pone.0074641. eCollection 2013.

Myc-dependent genome instability and lifespan in Drosophila.

Author information

1
Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, United States of America.

Abstract

The Myc family of transcription factors are key regulators of cell growth and proliferation that are dysregulated in a large number of human cancers. When overexpressed, Myc family proteins also cause genomic instability, a hallmark of both transformed and aging cells. Using an in vivo lacZ mutation reporter, we show that overexpression of Myc in Drosophila increases the frequency of large genome rearrangements associated with erroneous repair of DNA double-strand breaks (DSBs). In addition, we find that overexpression of Myc shortens adult lifespan and, conversely, that Myc haploinsufficiency reduces mutation load and extends lifespan. Our data provide the first evidence that Myc may act as a pro-aging factor, possibly through its ability to greatly increase genome instability.

PMID:
24040302
PMCID:
PMC3765364
DOI:
10.1371/journal.pone.0074641
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Public Library of Science Icon for PubMed Central
Loading ...
Support Center