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J Clin Psychiatry. 1990 Jan;51(1):8-11.

What constitutes an adequate antidepressant trial for fluoxetine?

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Private Practice Research Group, University of Pennsylvania, Philadelphia.


One hundred and eight patients with major depression were treated with fluoxetine 20 mg/day for 3 weeks. Patients who failed to respond to this open-label treatment were randomly assigned either to receive fluoxetine 60 mg/day for 5 weeks or to continue treatment with fluoxetine 20 mg/day for an additional 5 weeks. Both treatment groups demonstrated a statistically significant reduction in depressive symptoms, indicating that continued treatment with low-dose fluoxetine may be as effective as an increase in dose in achieving a favorable clinical outcome.

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