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Chembiochem. 2013 Oct 11;14(15):1991-7. doi: 10.1002/cbic.201300205. Epub 2013 Sep 3.

Rhabdopeptides as insect-specific virulence factors from entomopathogenic bacteria.

Author information

1
Merck Stiftungsprofessur für Molekulare Biotechnologie, Fachbereich Biowissenschaften, Goethe Universität Frankfurt, 60438 Frankfurt am Main (Germany).

Abstract

Six novel linear peptides, named "rhabdopeptides", have been identified in the entomopathogenic bacterium Xenorhabdus nematophila after the discovery of the corresponding rdp gene cluster by using a promoter trap strategy for the detection of insect-inducible genes. The structures of these rhabdopeptides were deduced from labeling experiments combined with detailed MS analysis. Detailed analysis of an rdp mutant revealed that these compounds participate in virulence towards insects and are produced upon bacterial infection of a suitable insect host. Furthermore, two additional rhabdopeptide derivatives produced by Xenorhabdus cabanillasii were isolated, these showed activity against insect hemocytes thereby confirming the virulence of this novel class of compounds.

KEYWORDS:

Xenorhabdus; biosynthesis; insect inducible genes; natural products; promoter trap strategy; rhabdopeptides

PMID:
24038745
DOI:
10.1002/cbic.201300205
[Indexed for MEDLINE]

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