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Angew Chem Int Ed Engl. 2013 Oct 11;52(42):11021-4. doi: 10.1002/anie.201302374. Epub 2013 Aug 26.

Opsin, a structural model for olfactory receptors?

Author information

1
Division of Biotechnology, Advanced Institute of Environment and Bioscience, College of Environmental & Bioresources Sciences, Chonbuk National University, 570-752 Iksan (Republic of Korea). junghee.park@jbnu.ac.kr.

Abstract

Receptor-ligand interaction: Olfactory receptors (ORs) are G-protein-coupled receptors (GPCRs), which detect signaling molecules such as hormones and odorants. The structure of opsin, the GPCR employed in vision, with a detergent molecule bound deep in its orthosteric ligand-binding pocket provides a template for OR homology modeling, thus enabling investigation of the structural basis of the mechanism of odorant-receptor recognition.

KEYWORDS:

GPCR; homology modeling; olfactory receptor; protein structures; receptors

PMID:
24038729
DOI:
10.1002/anie.201302374
[Indexed for MEDLINE]

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