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Angew Chem Int Ed Engl. 2013 Oct 11;52(42):11063-7. doi: 10.1002/anie.201305109. Epub 2013 Sep 3.

Arimetamycin A: improving clinically relevant families of natural products through sequence-guided screening of soil metagenomes.

Author information

1
Laboratory of Genetically Encoded Small Molecules, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065 (USA) http://lab.rockefeller.edu/brady/

Abstract

Sequence-tag-guided screening of soil environmental DNA libraries can be used to guide the discovery of new compounds with improved properties. In heterologous expression experiments the eDNA-derived arm cluster encodes arimetamycin A, an anthracycline that is more potent than clinically used natural anthracyclines and retains activity against multidrug-resistant (MDR) cancer cells.

KEYWORDS:

MDR; anthracyclines; antitumor agents; metagenomics; natural products

PMID:
24038656
PMCID:
PMC3878715
DOI:
10.1002/anie.201305109
[Indexed for MEDLINE]
Free PMC Article
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