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Adv Mater. 2013 Nov 13;25(42):6083-8. doi: 10.1002/adma.201301938. Epub 2013 Aug 19.

Ultrabright organic dots with aggregation-induced emission characteristics for real-time two-photon intravital vasculature imaging.

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1
Department of Chemical and Biomolecular Engineering, National University of Singapore, 117576, Singapore.

Abstract

Ultrabright organic dots with aggregation-induced emission characteristics (AIE dots) are prepared and shown to exhibit a high quantum yield, a, large two-photon absorption cross-section, and low in vivo toxicity. Real-time two-photon intravital blood vascular imaging in various tissues substantiates that the AIE dots are effective probes for in vivo vasculature imaging in a deep and high-contrast manner.

KEYWORDS:

aggregation-induced emission; blood vascular imaging; nanoparticles; quantum dots; two-photon fluorescence imaging

PMID:
24038281
DOI:
10.1002/adma.201301938
[Indexed for MEDLINE]
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