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Clin Cardiol. 2013 Dec;36(12):737-42. doi: 10.1002/clc.22195. Epub 2013 Aug 27.

Methamphetamine-associated cardiomyopathy.

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1
John A. Burns School of Medicine University of Hawaii at Manoa Honolulu, Hawaii.

Abstract

Methamphetamine and related compounds are now the second most commonly used illicit substance worldwide, after cannabis. Reports of methamphetamine-associated cardiomyopathy (MAC) are increasing, but MAC has not been well reviewed. This analysis of MAC will provide an overview of the pharmacology of methamphetamine, historical perspective and epidemiology, a review of case and clinical studies, and a summary of the proposed mechanisms for MAC. Clinically, many questions remain, including the appropriate therapeutic interventions for MAC, the incidence and prevalence of cardiac pathology in methamphetamine users, risk factors for developing MAC, and prognosis of these patients. In conclusion, recognition of the significance of MAC among physicians and other medical caregivers is important given the growing use of methamphetamine and related stimulants worldwide.

PMID:
24037954
PMCID:
PMC4319790
DOI:
10.1002/clc.22195
[Indexed for MEDLINE]
Free PMC Article
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