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Chem Commun (Camb). 2013 Nov 4;49(85):9953-5. doi: 10.1039/c3cc45373a.

Metallo-toeholds: controlling DNA strand displacement driven by Hg(II) ions.

Author information

1
CAS Key Laboratory of Soft Matter Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China. hjliang@ustc.edu.cn.

Abstract

Toehold-mediated strand displacement is a powerful tool that permits programmable control over DNA hybridization. Here, we developed a mechanism for strand displacement driven by Hg(2+) ions, in which the insertion of thymine-thymine mismatched base pairs on the toeholds provides additional control through variation of the concentration of Hg(2+) ions.

PMID:
24036488
DOI:
10.1039/c3cc45373a
[Indexed for MEDLINE]

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