Relationships between serum omentin-1 concentration and bone mineral density, and bone biochemical markers in Chinese women

Background: Omentin-1, as a newly discovered adipocytokine, plays an important role in bone metabolism. However, the association between circulating omentin-1 level and bone mineral density (BMD) in Chinese women has never been investigated.

Methods: Serum omentin-1, adiponectin, leptin, bone turnover biochemical markers, BMD were determined in 225 premenopausal women and 285 postmenopausal women.

Results: In premenopausal Chinese women, omentin-1 level was significantly higher compared to postmenopausal women. The multiple linear stepwise regression analysis showed that lean mass, omentin-1 and weight were independent predictors of BMD in premenopausal women. Omentin-1 was negatively correlated with bone-specific alkaline phosphatase (BAP) and bone cross-linked N-terminal telopeptides of type I collagen (NTX) in premenopausal women. However the omentin-1 was not the predictor of BMD in postmenopausal women.

Conclusions: Omentin-1 is an independent predictor of BMD in premenopausal Chinese women, and shows a negative correlation with bone turnover biochemical markers. Our results suggest that omentin-1 may exert a negative effect on bone mass by inhibiting bone formation in premenopausal women.