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Acta Biomater. 2014 Jan;10(1):47-55. doi: 10.1016/j.actbio.2013.09.004. Epub 2013 Sep 12.

Single and dual crosslinked oxidized methacrylated alginate/PEG hydrogels for bioadhesive applications.

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Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.


A degradable, cytocompatible bioadhesive can facilitate surgical procedures and minimize patient pain and post-surgical complications. In this study a bioadhesive hydrogel system based on oxidized methacrylated alginate/8-arm poly(ethylene glycol) amine (OMA/PEG) has been developed, and the bioadhesive characteristics of the crosslinked OMA/PEG hydrogels evaluated. Here we demonstrate that the swelling behavior, degradation profiles, and storage moduli of crosslinked OMA/PEG hydrogels are tunable by varying the degree of alginate oxidation. The crosslinked OMA/PEG hydrogels exhibit cytocompatibility when cultured with human bone marrow-derived mesenchymal stem cells. In addition, the adhesion strength of these hydrogels, controllable by varying the alginate oxidation level and measured using a porcine skin model, is superior to commercially available fibrin glue. This OMA/PEG hydrogel system with controllable biodegradation and mechanical properties and adhesion strength may be a promising bioadhesive for clinical use in biomedical applications, such as drug delivery, wound closure and healing, biomedical device implantation, and tissue engineering.


Adhesion; Alginate; Bioadhesive; Biodegradation; Poly(ethylene glycol)

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