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Clin Nutr. 2014 Aug;33(4):626-33. doi: 10.1016/j.clnu.2013.08.005. Epub 2013 Aug 23.

Metabolic syndrome and functional ability in older age: the InCHIANTI study.

Author information

1
Area di Geriatria, Campus Bio-Medico University, Via Álvaro del Portillo, 200, 00128 Rome, Italy. Electronic address: lavoralice@gmail.com.
2
Geriatric Rehabilitation Unit, Azienda Sanitaria di Firenze, Florence, Italy.
3
UOS Accesso e Presa in Carico Assistenziale, Azienda Sanitaria Locale Roma E, Rome, Italy.
4
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, MD, USA.
5
Area di Geriatria, Campus Bio-Medico University, Via Álvaro del Portillo, 200, 00128 Rome, Italy.

Abstract

BACKGROUND & AIMS:

Metabolic syndrome (MetS) is associated with incident disability in middle-aged subjects. We evaluated the association of MetS with functional ability in an older population.

METHODS:

We enrolled 1155 participants aged 65+, derived from the InCHIANTI study, and followed for 3 years. MetS was diagnosed according to the National Cholesterol Education Program's ATP-III criteria. Functional ability was estimated using the Katz's activities of daily living (ADLs), and the Lawton and Brody for the instrumental activities of daily living (IADLs) scales. The association between disability and MetS at baseline and after follow-up was assessed by logistic regression.

RESULTS:

At baseline, MetS was associated with reduced probability of ADLs disability among participants aged 74+ (OR = .33, 95% CI = .14-.77; p = .010), but not in younger (5.08, 95% CI = .88-29.24; p = .069). Also, MetS was associated with reduced probability of incident ADLs disability (OR = .61, 95% CI .41-.91; p = .016), but neither with prevalent, nor incident IADLs disability.

CONCLUSIONS:

In older persons, MetS is associated with reduced probability of prevalent and incident ADLs disability. Whether older persons with MetS should receive treatment and whether the current diagnostic criteria for MetS apply to older individuals need further investigation.

KEYWORDS:

Disability; Elderly; Epidemiology; Metabolic syndrome

PMID:
24035348
PMCID:
PMC6121716
DOI:
10.1016/j.clnu.2013.08.005
[Indexed for MEDLINE]
Free PMC Article

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