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Eur J Obstet Gynecol Reprod Biol. 2013 Nov;171(1):161-5. doi: 10.1016/j.ejogrb.2013.08.036. Epub 2013 Sep 2.

Measurement of uterine fibroid volume: a comparative accuracy and validation of methods study.

Author information

1
Department of Obstetrics and Gynaecology, St. Mary's Hospital, Praed Street, London W2 1NY, United Kingdom. Electronic address: Stephen.quinn@imperial.nhs.uk.

Abstract

OBJECTIVE:

A range of measurement techniques have been described which may be used to calculate uterine fibroid volume. A commonly-reported method involves application of a formula for the volume of an ellipsoid sphere to three orthogonal axes of a fibroid as measured on cross-sectional images. We aimed to compare this method and a second method, that of software-computed parallel planimetric uterine fibroid computation on MRI images, to a gold standard: the volume of objects measured by water displacement. We also compared these methods in volume estimation of patient fibroids using MRI data.

STUDY DESIGN:

Mixed observational study and blinded cross-sectional analysis of imaging data.

RESULTS:

Large inter-observer variability was noted when using the ellipsoid formula method, which was also inaccurate when compared to the gold standard. Conversely, the parallel planimetric method showed excellent interobserver correlation and a high degree of correlation with gold standard volume measurements.

CONCLUSION:

We conclude that the parallel planimetric method, although a more complex and time consuming technique, is the more accurate and therefore preferred method for measuring uterine fibroid volume.

KEYWORDS:

Focused ultrasound; Leiomyoma; Measurement accuracy; Uterine fibroids; Validation

PMID:
24035324
DOI:
10.1016/j.ejogrb.2013.08.036
[Indexed for MEDLINE]

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