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Phytomedicine. 2014 Jan 15;21(2):101-8. doi: 10.1016/j.phymed.2013.08.009. Epub 2013 Sep 12.

Sauchinone from Saururus chinensis protects vascular inflammation by heme oxygenase-1 induction in human umbilical vein endothelial cells.

Author information

1
Hanbang Body-fluid Research Center, Wonkwang University, Shinyong-dong, Iksan Jeonbuk, 570-749, Republic of Korea.
2
College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University, Shinyong-dong, Iksan, Jeonbuk 570-749, Republic of Korea; Hanbang Body-fluid Research Center, Wonkwang University, Shinyong-dong, Iksan Jeonbuk, 570-749, Republic of Korea.
3
Standardized Material Bank for New Botanical Drugs; College of Pharmacy, Wonkwang University, Iksan 570-749, Republic of Korea.
4
College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University, Shinyong-dong, Iksan, Jeonbuk 570-749, Republic of Korea; Hanbang Body-fluid Research Center, Wonkwang University, Shinyong-dong, Iksan Jeonbuk, 570-749, Republic of Korea. Electronic address: dgkang@wku.ac.kr.
5
College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University, Shinyong-dong, Iksan, Jeonbuk 570-749, Republic of Korea; Hanbang Body-fluid Research Center, Wonkwang University, Shinyong-dong, Iksan Jeonbuk, 570-749, Republic of Korea. Electronic address: host@wku.ac.kr.

Abstract

Sauchinone, a diastereomeric lignan isolated from the roots of Saururus chinensis (LOUR.) BAILL. (Saururaceae), is reported to exert a variety of biological activities such as hepatoprotective, anti-inflammatory actions and inhibitory effects on bone resorption. In this study, we investigated the effect of sauchinone in suppressing cell adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) and intracellular adhesion molecule-1 (ICAM-1) expression in high glucose stimulated human umbilical vein endothelial cells (HUVEC). Sauchinone inhibited the phosphorylation and degradation of IκB-α, as well as the nuclear translocation of nuclear factor kappa B (NF-κB) p65 caused by the stimulation of high glucose. In addition, sauchinone induced heme oxygenase (HO)-1 expression through nuclear translocation of nuclear factor E2-related factor 2 in HUVEC. The effects of sauchinone on the high glucose-induced expression of VCAM-1 and ICAM-1 and nuclear translocation of NF-κB p65 were partially reversed by transfection of the cells with HO-1 siRNA. These findings suggest that sauchinone-induced HO-1 expression plays a key role in the vascular protective effects of sauchinone in HUVEC.

KEYWORDS:

Atherosclerosis; HUVEC; Heme oxygenase-1; NF-κB; Sauchinone

PMID:
24035224
DOI:
10.1016/j.phymed.2013.08.009
[Indexed for MEDLINE]

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