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Res Vet Sci. 2013 Dec;95(3):831-6. doi: 10.1016/j.rvsc.2013.08.015. Epub 2013 Aug 29.

Dog obesity--the need for identifying predisposing genetic markers.

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1
Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wołynska 33, 60-637 Poznan, Poland. Electronic address: switonsk@jay.up.poznan.pl.

Abstract

Incidence of overweight and obesity in dogs exceeds 30%, and several breeds are predisposed to this heritable phenotype. Rapid progress of canine genomics and advanced knowledge on the genetic background of human obesity bring a unique opportunity to perform such studies in dogs. Natural candidate genes for obesity are these encoding adipokines. Extended studies in humans indicated that polymorphisms of three of them, i.e. ADIPOQ, IL1 and TNF, are associated with predisposition to obesity. On the other hand, the use of genome-wide association studies revealed an association between human obesity and polymorphism of more than 50 other genes. Until now only few preliminary reports on polymorphism of canine FTO, MC4R, MC3R and PPARG genes have been published. Since the dog is a valuable model organism for human diseases one can foresee that such studies may also contribute to an in-depth understanding of human obesity pathogenesis.

KEYWORDS:

Adipokines; Dog; FTO; Human; MC4R; Obesity

PMID:
24034586
DOI:
10.1016/j.rvsc.2013.08.015
[Indexed for MEDLINE]
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