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Cell. 2013 Sep 12;154(6):1194-205. doi: 10.1016/j.cell.2013.08.053.

The regulation of cell size.

Author information

1
MRC Laboratory for Molecular Cell Biology and the UCL Cancer Institute, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: alison.lloyd@ucl.ac.uk.

Abstract

An adult animal consists of cells of vastly different size and activity, but the regulation of cell size remains poorly understood. Recent studies uncovering some of the signaling pathways important for size/growth control, together with the identification of diseases resulting from aberrations in these pathways, have renewed interest in this field. This Review will discuss our current understanding of how a cell sets its size, how it can adapt its size to a changing environment, and how these processes are relevant to human disease.

PMID:
24034244
DOI:
10.1016/j.cell.2013.08.053
[Indexed for MEDLINE]
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