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Cell. 2013 Sep 12;154(6):1186-7. doi: 10.1016/j.cell.2013.08.037.

Intrinsic activity of odorant receptors guides sensory map formation.

Author information

1
Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute and QB3 Functional Genomics Laboratory, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: jngai@berkeley.edu.

Abstract

Olfactory sensory neurons innervate the olfactory bulb in stereotyped patterns according to the odorant receptors they express. A study by Nakashima et al. in this issue demonstrates that the odorant receptor's level of intrinsic activity-in the absence of activating odorant-influences the guidance of olfactory axons to their targets.

PMID:
24034241
PMCID:
PMC3865890
DOI:
10.1016/j.cell.2013.08.037
[Indexed for MEDLINE]
Free PMC Article

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