Format

Send to

Choose Destination
Cell. 2013 Sep 12;154(6):1184-6. doi: 10.1016/j.cell.2013.08.040.

Self-eating limits EGFR-dependent tumor growth.

Author information

1
Oncology Research Unit, Pfizer Worldwide Research and Development, La Jolla, CA 92121, USA.

Abstract

Autophagy is a cell-autonomous, catabolic process that plays context-dependent roles in tumor growth and progression. Wei et al. report that EGFR signaling promotes tumor growth through phosphorylation and functional inactivation of Beclin 1 and the consequent suppression of autophagy.

PMID:
24034240
DOI:
10.1016/j.cell.2013.08.040
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center