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Br J Haematol. 2013 Nov;163(3):400-3. doi: 10.1111/bjh.12517. Epub 2013 Aug 16.

Impact of heart magnetic resonance imaging on chelation choices, compliance with treatment and risk of heart disease in patients with thalassaemia major.

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Clinica Pediatrica 2, Ospedale Regionale per le Microcitemie, ASL 8 Cagliari, Cagliari, Italy.


This study aimed to verify the impact of heart magnetic resonance imaging on chelation choices and patient compliance in a single-institution cohort as well as its predictive value for heart failure and arrhythmias. Abnormal cardiac T2* values determined changes in treatment in most subjects. Heart T2* was confirmed to be highly predictive over 1 year for heart failure and arrhythmias. The choice of chelation regimens known to remove heart iron efficiently was not sufficient by itself to influence the risk. Compliance with treatment had a more remarkable role.


arrhythmia; beta thalassaemia major; compliance; heart failure; heart magnetic resonance imaging

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